An in vitro model of chronic wounding and its implication for age-related macular degeneration.
Degeneration of the retinal pigment epithelium (RPE) plays a central role in age-related macular degeneration (AMD).Throughout life, RPE cells are challenged by a variety of cytotoxic stressors, some of which are cumulative with age and may ultimately contribute to drusen and lipofuscin accumulation.Stressors such as these continually damage RPE ce